Product DescriptionGYY4137 is one of the synthetic hydrogen sulfide donors derived from Lawsson’s reagent. It is water-soluble and releases H2S very slowly by hydrolysis in aqueous solutions. GYY4137 has shown distinct cellular effects such as anti-hypertensive, anti-atherosclerotic and anti-tumor activities in several reports.
Fig. 1 H2S Releasing Mechanism of GYY4137
Fig. 2 H2S Releasing Curve of GYY4137 in PBS (100 μM)
1. L. Li, M. Whiteman, Y. Y. Guan, K. L. Neo, Y. Cheng, S. W. Lee, Y. Zhao, R. Baskar, C- H. Tang and P. K. Moore,Circulation, 2008, 117, 2351.2. Z. Liu, Y. Han, L. Li, H. Li, G. Meng, X. Li, M. Shirhan, M. T. Peh, L. Xie, S. Zhou, X. Wang, Q. Chen, W. Dai,C-H. Tang, S. Pan, P.K. Moore, and Y. Ji, Br J Pharmacol.,2013, 169, 1795.3. Z. W. Lee, J. Zhou, C-S Chen, Y. Zhao, C-H. Tan, L Li, P. K. Moore and L-W. Deng, PLoS One., 2011, 6, e21077.
Related Categories Sulfur Biology Oxidative Stress Assay
