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商品详细Dojindo/S-亚硝基谷胱甘肽/100/N415
Dojindo/S-亚硝基谷胱甘肽/100/N415
Dojindo/S-亚硝基谷胱甘肽/100/N415
商品编号: N415
品牌: 同仁
市场价: ¥8120.00
美元价: 4872.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionReferencesS.D.S
Reaction of NO release

Product Description of S-NitrosothiolsNitrosothiol compounds release NO and become disulfides under specific physiological conditions. While most of the S-nitrosothiol compounds are unstable, S-Nitrosoglutathione is exceptionally stable. Furthermore, S-Nitrosoglutathione is water-soluble. Although S-nitrosothiol is a good NO donor with no nitrate tolerance, there is evidence that S-nitrosothiol itself has NO-like activity during guanylate cyclase activation. Another important reaction of nitrosothiol is NO transfer to other thiol compounds. Since it depends on the pKa of thiols, this transfer reaction proceeds at physiological pH levels. The relaxation efficiency of these nitrosothiol has been compared using rataprta ring samples:SNAP > S – N i t r o s o g l u t a t h i o n e = S – N i t r o s o – N -acetylcysteine>S-Nitrosocoenzyme A>S-Nitroso-L-cysteine. Dr. Kowaluk and others reported that the spontaneous liberation of NO from SNAP could not account for in vitro vascular relaxation. The spontaneous release of NO from nitrosothiol compounds may not be a key element of vascular relaxation. Metabolites of nitrosothiol generated at the cell membrane might be the essential element for relaxation.

1. A. Gibson, et al., An Investigation of Some S-Nitrosothiols, and of Hydroxy-arginine, on the Mouse Anococcygeus. Br J Pharmacol. 1992;107:715-721.2. M. W. Radomski, et al., S-Nitroso-glutathione Inhibits Platelet Activation in Vitro and in Vivo. Br J Pharmacol. 1992;107:745-749.3. R. M. Clancy, et al., Novel Synthesis of S-Nitrosoglutathione and Degradation by Human Neutrophils. Anal Biochem. 1992;204:365-371.4. J. W. Park, et al., Transnitrosation as a Predominant Mechanism in the Hypotensive Effect of S-Nitrosoglutathione. Biochem Mol Biol Int. 1993;30:885-891.5. D. Barrachina, et al., Nitric Oxide Donors Preferencially Inhibit Neuronally Mediated Rat Gastric Acid Secretion. Eur J Pharmacol. 1994;262:181-183.6. E. A. Konorev, et al., S-Nitrosoglutathione Improves Functional Recovery in the Isolated Rat Heart After Cardioplegic Ischemic Arrest-evidence for a Cardioprotective Effect of Nitric Oxide. J Pharmacol Exp Ther. 1995;274:200-2006.7. S. C. Askew, et al., Catalysis by Cu2+ of Nitric Oxide Release from S-Nitrosothiols (RSNO). J Chem Soc Perkin Trans 2. 1995;741-745.8. D. J. Banett, et al., NO-group Transfer(Transnitrosation) between S-Nitrosothiols and Thiols. Part 2. J Chem Soc Perkin Trans 2. 1995;1279-1282.9. J. G. De Man, et al., Effect of Cu2+ on Relaxations to the Nitrergic Neurotransmitter, NO and S-Nitrosothiols in the Rat Gastric Fundus. Br J Pharmacol. 1996;119:990-996.10. A. P. Dicks, et al., Generation of Nitric Oxide from S-Nitrosothiols Using Protein-bound Cu2+ Sources. Chem Biol. 1996;3:655-659.11. J. A. Cook, et al., Convenient Colorimetric and Fluorometric Assays for S-Nitrosothiols. Anal Biochem. 1996;238:150-158.12. S. X. Liu, et al., Nitric Oxide Donors: Effects of S-Nitrosoglutathione and 4-Phenyl-3-furoxancarbonitrile on Ocular Blood Flow and Retinal Function Recovery. J Ocul Pharmacol Ther. 1997;13:105-114.13. C. Alpert, et al., Detection of S-Nitrosothiols and Other Nitric Oxide Derivatives by Photolysis-chemiluminescence Spectrometry. Anal Biochem. 1997;245:1-7.14. T. Akaike, et al., Nanomolar Quantification and Identification of Various Nitrosothiols by High Performance Liquid Chromatography Coupled with Flow Reactors of Metals and Griess Reagent. J Biochem. 1997;122:459-466.

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品牌介绍
Dojindo细胞分析细胞活力和细胞毒性测定用于药物筛选和化学物质的细胞毒性测试。Dojindo开发了高度水溶性的四唑盐,称为WST。WST-8是高度稳定的WST,用于Cell Counting Kit-8(CCK-8)。由于WST-8甲maz是水溶性的,因此不会形成晶体。因此,不需要诸如MTT测定的增溶过程。此外,CCK-8的检测灵敏度高于其他四唑盐,例如MTT,XTT,MTS或WST-1。WST检测机制 ß-半乳糖苷酶检测试剂细胞增殖/细胞毒性转染细胞染色细胞内荧光探针细菌染色微生物活力测定干细胞分化SPiDER-ßGal线粒体检测细胞代谢应用产品展示细胞生长检测,药物筛选,比色/荧光检测细胞计数试剂盒-8细胞计数试剂盒8 + 96孔有机硅定向剂细胞计数试剂盒-F细胞毒性LDH检测试剂盒-WST 96孔有机硅定向剂MTT了解检测机制的差异:点击这里细胞周期分析细胞周期测定溶液深红色细胞周期测定溶液蓝色